Welcome to Kinases encoded in Genomes database


Kinases encoded in Genomes is a comprehensive collection of Ser/Thr/Tyr specific protein kinases and similar sequences encoded in the completed genomes of eukaryotes and prokaryotes. This site provides a detailed classification based on sequence similarity of eukaryotic protein kinases (Hanks and Hunter classification). The assignment of functional domains to the gene products containing the kinase catalytic domain is also available. A domain combination based search tool on this site enables the retrieval of list of protein kinases with specified functional domain combinations in both bacterial and eukaryotic genomes. A search tool for the presence of kinase catalytic domain and the critical functional residues(if any) in the query sequence is also provided.

Reference: A. Krupa, K.R. Abhinandan & N. Srinivasan (2004) KinG: A database of protein Kinases IN Genomes. Nucl. Acids Res. 32, 153-155.

Database Update

  • KinG database is updated on April 27, 2019

  • KinG now holds information on over 230000 kinases encoded in over 2000 organisms. This includes kinases encoded by prokaryotes, eukaryotes and viruses.

External Links

  • Kinase.com
  • Kinase Pathway Database
  • Signal Transduction Knowledge Environment
  • Phosphobase-a Database of Phosphorylation Sites
  • The Protein Kinase Resource: (new link!)Curated database of protein kinase structures and related data
  • The Kinase Knowledgebase (KKB): Database of kinase structure-activity and chemical synthesis data.
  • Kinase Validation Data: Freely available kinase structure-activity datasets.
  • Kinase.Com: Genomics, evolution and large-scale analysis of protein kinases (non-commercial).
  • Kinase3D: A Database of Protein Kinase 3D homology models provided by GEN2X
  • Kinase/TIP: DB containing 1000s of protein structures, co-complexes and models surveying the Human Kinome.
  • Kinasecentral: Information on Kinase inhibitors in development
  • Collection of Ser/Thr/Tyr specific protein kinases and similar sequences
  • KinMutBase: A registry of disease-causing mutations in protein kinase domains
  • Human kinome by Manning et al.
  • Kinase Substrate Profiling Microarray: Microfluidic microarrays for customized kinase substrate profiling
  • Profiling for kinase inhibitors: Radioisotope based gold standard kinase assays
  • Kinase inhibitor lead identification & selectivity profiling: Active-site competitive binding kinase assays
  • KinBase
  • The Human Kinome diagram
  • Rice Kinome Database

  • Contact Us


    Prof. N. Srinivasan

    Lab Number: 103,
    Molecular Biophysics Unit, Indian Institute of Science,
    Bangalore 560 012, Karnataka, INDIA.

    Email : ns@iisc.ac.in
    Phone : +91-80-22932837
    Fax : +91-80-23600535